Docking is a computational technique that samples conformations of small molecules in
protein binding sites; scoring functions are used to assess which of these conformations best …

Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify
candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although …

Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids
such as dexamethasone (DEX) and is a hallmark of cachectic syndromes associated with …

Increasing competition in the market, due to the application of modern manufacturing technology,
deregulation of economies, and privatization or corporatization of government owned …

Modern treatment strategies have led to improvements in cancer survival, however, these
gains might be offset by the potential negative effect of cancer therapy on cardiovascular health…

Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic)
and catabolic (or atrophic) processes. Previously, no link between the molecular mediators …

Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and
fusion of myoblast precursors 1 . Skeletal muscle atrophy and hypertrophy refer to changes in …

Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and
PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated …

In this update of the Canadian Cardiovascular Society heart failure (HF) guidelines, we provide
comprehensive recommendations and practical tips for the pharmacologic management …

Metallo β-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis
of β-lactam antibiotics. This relatively new form of resistance is spreading unchallenged …