User profiles for Bridget A Knight
 | Bridget KnightVerified email at ex.ac.uk Cited by 15247 |
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the …
The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1 (SUR1)
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …
and inwardly rectifying potassium channel (Kir6.2) of the β-cell ATP-sensitive potassium (K …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
[HTML][HTML] The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells
Aims/hypothesis Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency.
Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/…
Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/…
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
…, W Kiess, TO Kilpeläinen, N Klopp, BA Knight… - Nature …, 2013 - nature.com
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…
the mechanisms behind these associations are poorly understood 1 . Previous genome-…
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide
association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and …
association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and …
Markers of β-cell failure predict poor glycemic response to GLP-1 receptor agonist therapy in type 2 diabetes
OBJECTIVE To assess whether clinical characteristics and simple biomarkers of β-cell failure
are associated with individual variation in glycemic response to GLP-1 receptor agonist (…
are associated with individual variation in glycemic response to GLP-1 receptor agonist (…
[HTML][HTML] Lower circulating B12 is associated with higher obesity and insulin resistance during pregnancy in a non-diabetic white British population
Objective Vitamin B12 and folate are critical micronutrients needed to support the increased
metabolic demands of pregnancy. Recent studies from India have suggested that low …
metabolic demands of pregnancy. Recent studies from India have suggested that low …
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis
…, M Meems, B Vaidya, L Chen, BA Knight… - The lancet Diabetes & …, 2020 - thelancet.com
Background Adequate transplacental passage of maternal thyroid hormone is important for
normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism …
normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism …
[HTML][HTML] Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared genetic …
well-known associations of childhood BMI with adult diseases are explained by shared genetic …
Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-α/hepatocyte nuclear factor 4-α maturity-onset diabetes of the …
OBJECTIVE Hepatocyte nuclear factor 1-α (HNF1A)/hepatocyte nuclear factor 4-α (HNF4A)
maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 diabetes, …
maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 diabetes, …