A prospective study was performed to establish criteria for the microbiological diagnosis of
prosthetic joint infection at elective revision arthroplasty. Patients were treated in a …

Background The management of complex orthopedic infections usually includes a prolonged
course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is …

Fracture-related infection (FRI) is a severe complication after bone injury and can pose a
serious diagnostic challenge. Overall, there is a limited amount of scientific evidence regarding …

Objectives Provision of outpatient parenteral antimicrobial therapy (OPAT) is an evolving field,
facilitating discharge from hospital for selected patients with serious infections. We report …

Culture of multiple periprosthetic tissue samples is the current gold standard for microbiological
diagnosis of prosthetic joint infections (PJI). Additional diagnostic information may be …

Prosthetic joint infection (PJI) complicates ∼1% of arthroplasties but accounts for considerable
morbidity. Both the timing and features of PJI can vary widely. Patients may present with …

Background Prosthetic joint infections are clinically difficult to diagnose and treat. Previously,
we demonstrated metagenomic sequencing on an Illumina MiSeq replicates the findings of …

Background For the diagnosis of prosthetic joint infection (PJI) automated BACTEC™ blood
culture bottle methods have comparable sensitivity, specificity and a shorter time to positivity …

Background Debridement-antibiotics-and-implant-retention (DAIR) may be considered a
suitable surgical option in periprosthetic joint infections (PJIs) with soundly fixed prostheses, …

Aims This study aimed to investigate the role of quantitative histological analysis in the
diagnosis of fracture-related infection (FRI). Patients and Methods The clinical features, …