The number of older people, including those living with dementia, is rising, as younger age
mortality declines. However, the age-specific incidence of dementia has fallen in many …

The increasing age of the population around the world has meant that greater attention is
being paid to disorders that mainly affect older people. In particular, work is focusing on ways …

Background Up-to-date evidence about levels and trends in disease and injury incidence,
prevalence, and years lived with disability (YLDs) is an essential input into global, regional, …

Background Measuring disease and injury burden in populations requires a composite metric
that captures both premature mortality and the prevalence and severity of ill-health. The …

Background Non-fatal health outcomes from diseases and injuries are a crucial consideration
in the promotion and monitoring of individual and population health. The Global Burden of …

The construct of mild cognitive impairment ( MCI ) has evolved over the past 10 years since
the publication of the new MCI definition at the K ey S ymposium in 2003, but the core criteria …

Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …

Background 100 years after the first description, Alzheimer's disease is one of the most
disabling and burdensome health conditions worldwide. We used the Delphi consensus method …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features
seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …