The prediction of transcription factor (TF) activities from the gene expression of their targets (ie,
TF regulon) is becoming a widely used approach to characterize the functional status of …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

Many methods allow us to extract biological activities from omics data using information from
prior knowledge resources, reducing the dimensionality for increased statistical power and …

Background Many functional analysis tools have been developed to extract functional and
mechanistic insight from bulk transcriptome data. With the advent of single-cell RNA …

Background & Aims In chronic liver diseases, inflammation induces oxidative stress and thus
may contribute to the progression of liver injury, fibrosis, and carcinogenesis. The KEAP1/…

Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant
hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that …

Transcriptome profiling followed by differential gene expression analysis often leads to lists
of genes that are hard to analyze and interpret. Functional genomics tools are powerful …

Methods From 2005 to 2009, medical expert committees and mediation boards reviewed 1528
cases of alleged treatment errors relating to injections. Results 278 cases were identified …

Mouse models of non-alcoholic fatty liver disease (NAFLD) are required to define therapeutic
targets, but detailed time-resolved studies to establish a sequence of events are lacking. …

Background Transcriptomic studies have contributed to fundamental knowledge of myocardial
remodeling in human heart failure (HF). However, the key HF genes reported are often …