The internal face of the detrusor smooth muscle wall of the urinary bladder is covered by a
mucosa, separating muscle from the hostile environment of urine. However, the mucosa is …

The isolated bladder shows autonomous micromotions, which increase with bladder
distension, generate sensory nerve activity, and are altered in models of urinary dysfunction. …

Bladder suburothelial myofibroblasts may modulate both sensory responses from the bladder
wall and spontaneous activity. This study aimed to characterize further these cells in their …

A loss of ability of cells to undergo apoptosis (programmed cell death, whereby the cell
ceases to function and destroys itself) is commonly associated with cancer, and many anti-cancer …

OBJECTIVE To identify particular purinoceptor subtypes by immunohistochemical labelling,
as a layer of suburothelial myofibroblasts has been identified in the urinary bladder, and …

BACKGROUND: An increasing body of evidence suggests a possible role of suburothelial
myofibroblasts (MFs) in bladder mechanosensation and in the pathophysiology of detrusor …

AP Conduction in Hypertrophied Myocardium. Introduction: Cardiac hypertrophy is
associated with an increased incidence of arrhythmias that result from altered action potential …

Background— Gap junction resistivity, R j , has been proposed as a key determinant of
conduction velocity (CV). However, studies in connexin-gene knockout mice demonstrated …

Characterizing the integrative physiology of the bladder requires whole organ preparations.
The purpose of this study was to validate an isolated large animal (pig) bladder preparation, …

Electrical correlates of the physiological state of a cell, such as membrane conductance and
capacitance, as well as cytoplasm conductivity, contain vital information about cellular …