User profiles for Christopher Larkin

C Larkin

- Verified email at medimmune.com - Cited by 2937

Christopher Larkin

- Verified email at mail.bbk.ac.uk - Cited by 254

The Genome of the African Trypanosome Trypanosoma brucei

…, AX Kerhornou, H Koo, N Larke, S Landfear, C Larkin… - science, 2005 - science.org
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan
Africa. We present the sequence and analysis of the 11 megabase-sized …

A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies

…, WK Chung, JH Thompson, C Larkin… - Biotechnology …, 2014 - Wiley Online Library
Co‐purification of a subset of host cell proteins (HCPs) with monoclonal antibodies (mAbs)
during the capture of mAbs on Protein A affinity chromatography is primarily caused by …

[PDF][PDF] Structural insights into single-stranded DNA binding and cleavage by F factor TraI

S Datta, C Larkin, JF Schildbach - Structure, 2003 - cell.com
Conjugative plasmid transfer between bacteria disseminates antibiotic resistance and
diversifies prokaryotic genomes. Relaxases, proteins essential for conjugation, cleave one …

The hybrid search: a mass spectral library search method for discovery of modifications in proteomics

…, J Heidbrink Thompson, C Larkin… - Journal of proteome …, 2017 - ACS Publications
We present a mass spectral library-based method to identify tandem mass spectra of peptides
that contain unanticipated modifications and amino acid variants. We describe this as a “…

Testing local descriptive norms and salience of enforcement action: A field experiment to increase tax collection

C Larkin, M Sanders, I Andresen… - Available at SSRN …, 2018 - papers.ssrn.com
The use of behavioural science interventions, and particularly social norms, in tax compliance
has become a growth industry for scholars and practitioners alike in recent years. However…

Using fluorophore-labeled oligonucleotides to measure affinities of protein–DNA interactions

BJ Anderson, C Larkin, K Guja, JF Schildbach - Methods in enzymology, 2008 - Elsevier
Abstract Changes in fluorescence emission intensity and anisotropy can reflect changes in
the environment and molecular motion of a fluorophore. Researchers can capitalize on these …

[PDF][PDF] Inter-and intramolecular determinants of the specificity of single-stranded DNA binding and cleavage by the F factor relaxase

C Larkin, S Datta, MJ Harley, BJ Anderson, A Ebie… - Structure, 2005 - cell.com
The TraI protein of conjugative plasmid F factor binds and cleaves a single-stranded region
of the plasmid prior to transfer to a recipient. TraI36, an N-terminal TraI fragment, binds …

Rapid identification of biotherapeutics with label-free Raman spectroscopy

…, R Strouse, JB McGivney, C Larkin… - Analytical …, 2016 - ACS Publications
Product identification is a critical and required analysis for biotheraputics. In addition to
regulatory requirements for identity testing on final drug products, in-process identity testing is …

[HTML][HTML] A retractable lid in lecithin: cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein AI

…, J Ahn, A Glukhova, W Yuan, C Larkin… - Journal of Biological …, 2017 - ASBMB
Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport
by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the …

The sequence and analysis of Trypanosoma brucei chromosome II

…, J Song, A MacLeod, F Bringaud, C Larkin… - Nucleic acids …, 2003 - academic.oup.com
We report here the sequence of chromosome II from Trypanosoma brucei, the causative
agent of African sleeping sickness. The 1.2‐Mb pairs encode about 470 predicted genes …