The Genome of the African Trypanosome Trypanosoma brucei
…, AX Kerhornou, H Koo, N Larke, S Landfear, C Larkin… - science, 2005 - science.org
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan
Africa. We present the sequence and analysis of the 11 megabase-sized …
Africa. We present the sequence and analysis of the 11 megabase-sized …
A novel approach to monitor clearance of host cell proteins associated with monoclonal antibodies
…, WK Chung, JH Thompson, C Larkin… - Biotechnology …, 2014 - Wiley Online Library
Co‐purification of a subset of host cell proteins (HCPs) with monoclonal antibodies (mAbs)
during the capture of mAbs on Protein A affinity chromatography is primarily caused by …
during the capture of mAbs on Protein A affinity chromatography is primarily caused by …
[PDF][PDF] Structural insights into single-stranded DNA binding and cleavage by F factor TraI
S Datta, C Larkin, JF Schildbach - Structure, 2003 - cell.com
Conjugative plasmid transfer between bacteria disseminates antibiotic resistance and
diversifies prokaryotic genomes. Relaxases, proteins essential for conjugation, cleave one …
diversifies prokaryotic genomes. Relaxases, proteins essential for conjugation, cleave one …
The hybrid search: a mass spectral library search method for discovery of modifications in proteomics
…, J Heidbrink Thompson, C Larkin… - Journal of proteome …, 2017 - ACS Publications
We present a mass spectral library-based method to identify tandem mass spectra of peptides
that contain unanticipated modifications and amino acid variants. We describe this as a “…
that contain unanticipated modifications and amino acid variants. We describe this as a “…
Testing local descriptive norms and salience of enforcement action: A field experiment to increase tax collection
The use of behavioural science interventions, and particularly social norms, in tax compliance
has become a growth industry for scholars and practitioners alike in recent years. However…
has become a growth industry for scholars and practitioners alike in recent years. However…
Using fluorophore-labeled oligonucleotides to measure affinities of protein–DNA interactions
Abstract Changes in fluorescence emission intensity and anisotropy can reflect changes in
the environment and molecular motion of a fluorophore. Researchers can capitalize on these …
the environment and molecular motion of a fluorophore. Researchers can capitalize on these …
[PDF][PDF] Inter-and intramolecular determinants of the specificity of single-stranded DNA binding and cleavage by the F factor relaxase
C Larkin, S Datta, MJ Harley, BJ Anderson, A Ebie… - Structure, 2005 - cell.com
The TraI protein of conjugative plasmid F factor binds and cleaves a single-stranded region
of the plasmid prior to transfer to a recipient. TraI36, an N-terminal TraI fragment, binds …
of the plasmid prior to transfer to a recipient. TraI36, an N-terminal TraI fragment, binds …
Rapid identification of biotherapeutics with label-free Raman spectroscopy
…, R Strouse, JB McGivney, C Larkin… - Analytical …, 2016 - ACS Publications
Product identification is a critical and required analysis for biotheraputics. In addition to
regulatory requirements for identity testing on final drug products, in-process identity testing is …
regulatory requirements for identity testing on final drug products, in-process identity testing is …
[HTML][HTML] A retractable lid in lecithin: cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein AI
…, J Ahn, A Glukhova, W Yuan, C Larkin… - Journal of Biological …, 2017 - ASBMB
Lecithin:cholesterol acyltransferase (LCAT) plays a key role in reverse cholesterol transport
by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the …
by transferring an acyl group from phosphatidylcholine to cholesterol, promoting the …
The sequence and analysis of Trypanosoma brucei chromosome II
We report here the sequence of chromosome II from Trypanosoma brucei, the causative
agent of African sleeping sickness. The 1.2‐Mb pairs encode about 470 predicted genes …
agent of African sleeping sickness. The 1.2‐Mb pairs encode about 470 predicted genes …