Five primary dimensions of organization structure were defined and operationalized; (1)
specialization, (2) standardization, (3) formalization, (4) centralization, (5) configuration. From …

Aspects of organizational context that have been held to be relevant to organizational structure
were examined. Seven primary concepts of organizational context, viz.: origin and history…

Many cells grown in tissue culture adhere tightly to the underlying sub strate through
discrete regions of the plasma membrane, referred to as

Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions,
the regions where cells adhere to the underlying substratum. We have examined the …

Cell migration is a complex, highly regulated process that involves the continuous formation
and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the …

Studies of work behavior have been primarily processual as opposed to factorial. There has
been a great concentration on the one-case study and little systematic attempt to relate …

To facilitate a rapid response to environmental change, cells use scaffolding—or adaptor—proteins
to recruit key components of their signal-transduction machinery to specific …

The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions
at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal …

Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

Background Resistance to tyrosine kinase inhibitors in patients with chronic myeloid
leukemia (CML) and Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph-positive …