User profiles for Chuka Nwokolo
Chuka NwokoloProfessor of Gastroenterology, Warwick Medical School Verified email at uhcw.nhs.uk Cited by 5603 |
Next generation diagnostic modalities in gastroenterology–gas phase volatile compound biomarker detection
…, C Harmston, CU Nwokolo - Alimentary …, 2014 - Wiley Online Library
Background The detection of airborne gas phase biomarkers that emanate from biological
samples like urine, breath and faeces may herald a new age of non‐invasive diagnostics. …
samples like urine, breath and faeces may herald a new age of non‐invasive diagnostics. …
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
…, D Elphick, A Shenoy, CU Nwokolo… - The lancet …, 2019 - thelancet.com
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …
[HTML][HTML] Application of a novel tool for diagnosing bile acid diarrhoea
…, N O'Connell, J Cullis, N Williams, CU Nwokolo… - Sensors, 2013 - mdpi.com
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose.
We have tested the efficacy of a new method to identify BAD, based on the detection of …
We have tested the efficacy of a new method to identify BAD, based on the detection of …
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
…, A Thakur, D Elphick, A Shenoy, CU Nwokolo… - Gastroenterology, 2020 - Elsevier
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
Common variants at the MHC locus and at chromosome 16q24. 1 predispose to Barrett's esophagus
Barrett's esophagus is an increasingly common disease that is strongly associated with
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal …
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal …
[HTML][HTML] Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis
…, N O'Connell, C Bailey, C Harmston, CU Nwokolo… - PloS one, 2014 - journals.plos.org
Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA.
There is no universally accepted effective non-invasive screening test for CRC. Guaiac …
There is no universally accepted effective non-invasive screening test for CRC. Guaiac …
A randomized, double-blind, placebo-controlled, parallel-group, pilot study of cannabidiol-rich botanical extract in the symptomatic treatment of ulcerative colitis
Background Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve
disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, …
disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, …
[HTML][HTML] Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus
Background & Aims Barrett's esophagus (BE) increases the risk of esophageal
adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide …
adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide …
[HTML][HTML] Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled …
Background Up to 60% of patients with Crohn's disease need intestinal resection within the
first 10 years of diagnosis, and postoperative recurrence is common. We investigated …
first 10 years of diagnosis, and postoperative recurrence is common. We investigated …
[HTML][HTML] Differentiating coeliac disease from irritable bowel syndrome by urinary volatile organic compound analysis–a pilot study
…, S Chambers, N O'Connell, C Bailey, CU Nwokolo… - PloS one, 2014 - journals.plos.org
Coeliac disease (CD), a T-cell-mediated gluten sensitive enteropathy, affects ∼1% of the
UK population and can present with wide ranging clinical features, often being mistaken for …
UK population and can present with wide ranging clinical features, often being mistaken for …