User profiles for Chuka Nwokolo

Chuka Nwokolo

Professor of Gastroenterology, Warwick Medical School
Verified email at uhcw.nhs.uk
Cited by 5603

Next generation diagnostic modalities in gastroenterology–gas phase volatile compound biomarker detection

…, C Harmston, CU Nwokolo - Alimentary …, 2014 - Wiley Online Library
Background The detection of airborne gas phase biomarkers that emanate from biological
samples like urine, breath and faeces may herald a new age of non‐invasive diagnostics. …

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

…, D Elphick, A Shenoy, CU Nwokolo… - The lancet …, 2019 - thelancet.com
Background Anti-TNF drugs are effective treatments for the management of Crohn's disease
but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors …

[HTML][HTML] Application of a novel tool for diagnosing bile acid diarrhoea

…, N O'Connell, J Cullis, N Williams, CU Nwokolo… - Sensors, 2013 - mdpi.com
Bile acid diarrhoea (BAD) is a common disease that requires expensive imaging to diagnose.
We have tested the efficacy of a new method to identify BAD, based on the detection of …

[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease

…, A Thakur, D Elphick, A Shenoy, CU Nwokolo… - Gastroenterology, 2020 - Elsevier
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …

Common variants at the MHC locus and at chromosome 16q24. 1 predispose to Barrett's esophagus

…, WH Chow, M Rutter, A Tawil, D Morris, C Nwokolo… - Nature …, 2012 - nature.com
Barrett's esophagus is an increasingly common disease that is strongly associated with
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal …

[HTML][HTML] Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis

…, N O'Connell, C Bailey, C Harmston, CU Nwokolo… - PloS one, 2014 - journals.plos.org
Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA.
There is no universally accepted effective non-invasive screening test for CRC. Guaiac …

A randomized, double-blind, placebo-controlled, parallel-group, pilot study of cannabidiol-rich botanical extract in the symptomatic treatment of ulcerative colitis

PM Irving, T Iqbal, C Nwokolo… - Inflammatory bowel …, 2018 - academic.oup.com
Background Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve
disease activity in inflammatory bowel disease. This proof-of-concept study assessed efficacy, …

[HTML][HTML] Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus

…, I Murray, K Koss, A Veitch, N Trudgill, C Nwokolo… - Gastroenterology, 2015 - Elsevier
Background & Aims Barrett's esophagus (BE) increases the risk of esophageal
adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide …

[HTML][HTML] Mercaptopurine versus placebo to prevent recurrence of Crohn's disease after surgical resection (TOPPIC): a multicentre, double-blind, randomised controlled …

…, J Morris, J Hamlin, A Dhar, C Nwokolo… - The lancet …, 2016 - thelancet.com
Background Up to 60% of patients with Crohn's disease need intestinal resection within the
first 10 years of diagnosis, and postoperative recurrence is common. We investigated …

[HTML][HTML] Differentiating coeliac disease from irritable bowel syndrome by urinary volatile organic compound analysis–a pilot study

…, S Chambers, N O'Connell, C Bailey, CU Nwokolo… - PloS one, 2014 - journals.plos.org
Coeliac disease (CD), a T-cell-mediated gluten sensitive enteropathy, affects ∼1% of the
UK population and can present with wide ranging clinical features, often being mistaken for …