Background Pompe's disease is a metabolic myopathy caused by a deficiency of acid alpha
glucosidase (GAA), an enzyme that degrades lysosomal glycogen. Late-onset Pompe's …

Background. It is known that the age of transfused blood is a risk factor for the development
of multiple organ failure in surgical patients. However, the character of hemorrheological …

Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic
physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine …

In a previous 52-wk trial, treatment with alglucosidase alfa markedly improved cardiomyopathy,
ventilatory function, and overall survival among 18 children< 7 mo old with infantile-onset …

Purpose: A clinical trial was conducted to evaluate the safety and efficacy of alglucosidase
alfa in infants and children with advanced Pompe disease. Methods: Open-label, multicenter …

An immunosensor is a device comprising an antigen or antibody species coupled to a
signal transducer, which detects the binding of the complementary species. An indirect …

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2
diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer …

Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the
cellular and molecular processes that generate them are poorly understood. Here, we perform a …

Objective: To examine the perception and management of cardiovascular disease (CVD)
risk in Australian primary care. Design, setting and participants: The Australian Hypertension …

Background Angina, the cardinal symptom of coronary artery disease (CAD), is amenable to
a range of therapies, and its routine assessment is considered a performance measure of …