[PDF][PDF] Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital
…, AJ Gray, DJ Webb, JG Moggs, DN Bateman… - …, 2013 - Wiley Online Library
Acetaminophen overdose is a common reason for hospital admission and the most frequent
cause of hepatotoxicity in the Western world. Early identification would facilitate patient‐…
cause of hepatotoxicity in the Western world. Early identification would facilitate patient‐…
[HTML][HTML] Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial
DN Bateman, JW Dear, HKR Thanacoody… - The Lancet, 2014 - thelancet.com
Background Paracetamol poisoning is common worldwide. It is treated with intravenous
acetylcysteine, but the standard regimen is complex and associated with frequent adverse …
acetylcysteine, but the standard regimen is complex and associated with frequent adverse …
Comparison of consciousness level assessment in the poisoned patient using the alert/verbal/painful/unresponsive scale and the Glasgow Coma Scale
CA Kelly, A Upex, DN Bateman - Annals of emergency medicine, 2004 - Elsevier
STUDY OBJECTIVE: We determine how the alert/verbal/painful/unresponsive (AVPU)
responsiveness scale (alert, responsive to verbal stimulation, responsive to painful stimulation, …
responsiveness scale (alert, responsive to verbal stimulation, responsive to painful stimulation, …
Management of paracetamol poisoning
RE Ferner, JW Dear, DN Bateman - Bmj, 2011 - bmj.com
… Robin E Ferner honorary professor of clinical pharmacology1 2, James W Dear
consultant clinical pharmacologist3 4, D Nicholas Bateman professor of clinical toxicology3 …
consultant clinical pharmacologist3 4, D Nicholas Bateman professor of clinical toxicology3 …
Acetaminophen and acetylcysteine dose and duration: past, present and future
BH Rumack, DN Bateman - Clinical toxicology, 2012 - Taylor & Francis
Acetylcysteine has been utilized successfully in the treatment of acetaminophen overdose
since the 1970s. Although prospective trials as to efficacy and safety of acetylcysteine were …
since the 1970s. Although prospective trials as to efficacy and safety of acetylcysteine were …
The epidemiology of self‐poisoning in the UK
…, RJ Wood, DN Bateman - British journal of clinical …, 2003 - Wiley Online Library
Self‐poisoning by ingestion or inhalation is common, and it is important to study its various
epidemiological manifestations with clear definitions. Data on fatal self‐poisonings are …
epidemiological manifestations with clear definitions. Data on fatal self‐poisonings are …
Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment
DN Bateman, R Carroll, J Pettie… - British journal of …, 2014 - Wiley Online Library
Aims In S eptember 2012 the UK 's Commission on Human Medicines ( CHM ) recommended
changes in the management of paracetamol poisoning: use of a single ‘100 mg l −1 ’ …
changes in the management of paracetamol poisoning: use of a single ‘100 mg l −1 ’ …
[HTML][HTML] Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury
…, JI Clarke, LEJ Peeters, A Caporali, DN Bateman… - Scientific reports, 2015 - nature.com
Our objective was to identify microRNA (miRNA) biomarkers of drug-induced liver and
kidney injury by profiling the circulating miRNome in patients with acetaminophen overdose. …
kidney injury by profiling the circulating miRNome in patients with acetaminophen overdose. …
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose
Background. Adverse effects to N-acetylcysteine (NAC) are well recognized, but their
etiology and incidence are unclear. Methods. The nature and severity of adverse effects were …
etiology and incidence are unclear. Methods. The nature and severity of adverse effects were …
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous …
…, K Al-Hourani, M Eddleston, DN Bateman… - Clinical …, 2016 - Taylor & Francis
Context: Paracetamol (acetaminophen) overdose is a common reason for emergency
hospital admission in the UK and the leading cause of acute liver failure in the Western world. …
hospital admission in the UK and the leading cause of acute liver failure in the Western world. …