CD14, CD16 and HLA‐DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA‐DR expression by CD14hi/CD16neg monocytes: Expansion of CD14hi …

D Abeles, MJ McPhail, D Sowter… - Cytometry Part …, 2012 - Wiley Online Library
Abstract Changes in monocytes and their subsets (CD14 hi /CD16 neg , CD14 hi /CD16 pos
and CD14 lo /CD16 pos ) have been described in several diseases. The combination of …

Diagnostic and clinical utility of antibodies against the nuclear body promyelocytic leukaemia and Sp100 antigens in patients with primary biliary cirrhosis

…, C Probst, AL Koutsoumpas, D Abeles… - Clinica Chimica …, 2012 - Elsevier
BACKGROUND: The lack of an immunoassay that detects antibodies to promyelocytic
leukaemia (PML) protein, the primary biliary cirrhosis (PBC)-specific multiple nuclear dot (MND) …

[PDF][PDF] Circulating neutrophil dysfunction in acute liver failure

…, A Nishtala, GK Manakkat Vijay, RD Abeles… - …, 2013 - Wiley Online Library
Systemic inflammation and susceptibility to developing sepsis is common in acute liver failure
(ALF) resulting in tissue damage and organ failure. This study characterized the function of …

The impact of organ dysfunction in cirrhosis: survival at a cost?

DL Shawcross, MJ Austin, RD Abeles, MJW McPhail… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The incidence of cirrhosis and subsequent development of organ
dysfunction (OD) requiring intensive care unit (ICU) support is rising. Historically, critically ill …

Character and temporal evolution of apoptosis in acetaminophen-induced acute liver failure

…, A Quaglia, V Zingarelli, RD Abeles… - Critical care …, 2013 - journals.lww.com
Objective: To evaluate the role of hepatocellular and extrahepatic apoptosis during the
evolution of acetaminophen-induced acute liver failure. Design and Setting: A prospective …

[PDF][PDF] Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis

…, H Su, X Huang, MJ Hussain, RD Abeles… - …, 2013 - Wiley Online Library
… Fang Lin and Haibin Su were supported by scholarships from Beijing 302 Hospital, Robin
Daniel Abeles was supported by a clinician training fellowship from the National Institute for …

Dysfunctional neutrophil effector organelle mobilization and microbicidal protein release in alcohol-related cirrhosis

…, GKM Vijay, JM Ryan, RD Abeles… - American Journal …, 2017 - journals.physiology.org
Patients with alcohol-related cirrhosis (ALD) are prone to infection. Circulating neutrophils
in ALD are dysfunctional and predict development of sepsis, organ dysfunction, and survival. …

Androgenic anabolic steroid-induced liver injury: two case reports assessed for causality by the updated Roussel Uclaf Causality Assessment Method (RUCAM) score …

RD Abeles, M Foxton, S Khan… - BMJ open …, 2020 - bmjopengastro.bmj.com
Background Anabolic androgenic steroids (AAS) usage is widespread and increasing. AAS
drug-induced liver injury (DILI) is recognised but its clinical course and management is …

[HTML][HTML] Decision making in venous thromboembolism prophylaxis: Is LWMH being inappropriately withheld from patients admitted with chronic liver disease?

C Lau, C Burd, D Abeles, D Sherman - Clinical Medicine, 2015 - ncbi.nlm.nih.gov
Although chronic liver disease (CLD) constitutes a significant proportion of acute medical
admissions, it is not known how CLD influences venous thromboembolism (VTE) prophylaxis …

[HTML][HTML] Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

D Smyk, EI Rigopoulou, Y Zen, RD Abeles… - World Journal of …, 2012 - ncbi.nlm.nih.gov
Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the
immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The …