The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with
viral pneumonia. The most severely affected patients are older men, individuals of black and …

Background: Since publication of the 2012 Berlin definition of acute respiratory distress
syndrome (ARDS), several developments have supported the need for an expansion of the …

In patients requiring mechanical ventilation for acute lung injury or acute respiratory distress
syndrome (ARDS), tidal volume reduction decreases mortality, but the mechanisms of the …

Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the
intersititium and may play a role in abnormal alveolar permeability, which is a feature of …

Background: Lung protective ventilation has been widely adopted for the management of
acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Consequently, …

Introduction The autopsy has long been regarded as an important tool for confirming the
clinical cause of death, education and quality assurance. Concerns surrounding informed …

Alveolar epithelial–capillary barrier disruption is a hallmark of acute respiratory distress
syndrome (ARDS). Contribution of mitochondrial dysfunction to the compromised alveolar-…

Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein
rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of …

Secretory leucoprotease inhibitor (SLPI) is a neutrophil serine protease inhibitor constitutively
expressed at many mucosal surfaces, including that of the lung. Originally identified as a …

Ventilator-induced lung injury remains a key contributor to the morbidity and mortality of acute
respiratory distress syndrome (ARDS). Efforts to minimize this injury are typically limited by …