Sex differences exist in behaviors, disease and neuropsychiatric disorders. Sexual dimorphisms
however, have yet to be studied across the whole brain and across a comprehensive …

RhoA and its downstream target Rho kinase regulate serum response factor (SRF)-dependent
skeletal and smooth muscle gene expression. We previously reported that long-term …

Maternal environmental exposures, such as high-fat diets, diabetes and obesity, can induce
long-term effects in offspring. These effects include increased risk of neurodevelopmental …

Subepithelial fibrosis is one of the characteristic features of asthmatic airways. The fibrotic
response includes an increase in volume occupied by extracellular matrix (ECM) tissue, and a …

It is now accepted that a host of cytokines, chemokines, growth factors, and other inflammatory
mediators contributes to the development of nonspecific airway hyperresponsiveness in …

We have previously shown that glucocorticoids inhibit mitogen-stimulated proliferation of
human cultured airway smooth muscle (ASM) cells. The present study analyzed the effect of …

1 Airway smooth muscle proliferation is a significant component of the airway wall remodelling
that occurs in asthma. In this study, the effects of glucocorticoids on mitogenic responses …

An organizational pattern seen in the brain, termed structural covariance, is the statistical
association of pairs of brain regions in their anatomical properties. These associations, …

Bronchial hyperresponsiveness (BHR), the occurrence of excessive bronchoconstriction in
response to relatively small constrictor stimuli, is a cardinal feature of asthma. Here, we …

Airway wall remodeling, including hyperplasia of airway smooth muscle, is regarded as an
important contributor to airway hyperresponsiveness in asthmatic patients. The effects of the …