High-throughput screening (HTS) has been postulated in several quarters to be a contributory
factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been …

4-Amino- and 4-guanidino-4H-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167)
are a new class of inhibitors of influenza virus sialidases. Structure−activity studies reveal …

Here, we review the performance of chromatographic hydrophobicity measurements in a data
set of 100000 GlaxoSmithKline compounds, demonstrating the advantages of the method …

Background Current trial data may not be directly applicable to patients with the highest risk
presentations of atherosclerotic renovascular disease, including flash pulmonary edema, …

Sudden cardiac death (SCD) is the leading cause of death in hemodialysis patients,
accounting for death in up to one-quarter of this population. Unlike in the general population, …

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance
is widespread, no new chemical class of antimalarials has been introduced into clinical …

Using a novel interpretation of dynamic networks, we analyse the network of livestock
movements in Great Britain in order to determine the risk of a large epidemic of foot-and-mouth …

During the 2001 foot and mouth disease epidemic in the UK, initial dissemination of the disease
to widespread geographical regions was attributed to livestock movement, especially of …

Marine aquaculture relies on coastal habitats that will be affected by climate change. This
review assesses current knowledge of the threats and opportunities of climate change for …

We analyse the relationship between the network of livestock movements in the UK and the
dynamics of two diseases: foot-and-mouth disease (FMD), which has an incubation period of …