The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …

Fifty-eight patients with severe, progressive multiple sclerosis were prospectively
randomized to one of three treatments: 20 received intravenous ACTH, 20 received high-dose …

Multiple sclerosis (MS) is thought to be an autoimmune disease mediated by T lymphocytes
that recognize myelin components of the central nervous system. In a 1-year double-blind …

Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that is able to
make normal endothelial cells unresponsive to a wide variety of inducers. Here we use both …

The COVID-19 pandemic has profoundly altered the daily lives of many people across the
globe, both through the direct interpersonal cost of the disease, and the governmental …

… David Dawson insists that ancient allegory is best understood not simply as a way of reading
texts, but as a way of using non-literal readings to reinterpret culture and society. Here he …

The molecularheterogeneity of many proteins, particularly of individual enzymes, has recently
come to be clearly recognized. The various forms of these proteins are usually separable …

Background—Cilostazol is a new phosphodiesterase inhibitor that suppresses platelet
aggregation and also acts as a direct arterial vasodilator. This prospective, randomized, placebo-…

PURPOSE: We performed a randomized, double-blind, placebo-controlled, multicenter trial
to evaluate the relative efficacy and safety of cilostazol and pentoxifylline. PATIENTS AND …

The cystic fibrosis transmembrane conductance regulator (CFTR) is associated with
expression of a chloride conductance that is defective in cystic fibrosis (CF). Xenopus oocytes …