Type I interferon (IFN-α/β) is expressed rapidly following exposure to a wide variety of
infectious agents and plays a key role in innate control of virus replication. Recent studies have …

Differentiation of immature T and B cells in the primary lymphoid organs gives rise to a pool
of long-lived lymphocytes that recirculate through the secondary lymphoid tissues. On the …

Mature T cells are produced in the thymus and released into the bloodstream in low numbers.
These cells are considered to be immunologically naıve until such time as they encounter …

Proliferation of memory-phenotype (CD44 hi ) CD8 + cells induced by infectious agents can
be mimicked by injection of type I interferon (IFN I) and by IFN I–inducing agents such as …

T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal
response directed to various environmental antigens. However, the massive proliferation of …

Type I interferons (IFN-I) are rapidly induced following infection and play a key role in
nonspecific inhibition of virus replication. Here we have investigated the effects of IFN-I on the …

On the basis of their surface markers, T lymphocytes are divided into subsets of "naive" and "memory
cells". We have defined the interrelationship and relative life spans of naive and …

CD8 + T cell responses can be generated against antigens that are not expressed directly
within antigen-presenting cells (APCs), through a process known as cross-priming. To initiate …

Resting dendritic cells (DCs) are resident in most tissues and can be activated by environmental
stimuli to mature into potent antigen-presenting cells. One important stimulus for DC …

Recent studies suggest a hierarchical model in which lineage-determining factors act in a
collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-…