User profiles for David Holmes

David Holmes

Director, Center for Bioinformatics and Genome Biology, Fundacion Ciencia y Vida
Verified email at cienciavida.cl
Cited by 11918

[HTML][HTML] Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery

…, JJ Popma, PJ Fitzgerald, DR Holmes… - … England Journal of …, 2003 - Mass Medical Soc
Background Preliminary reports of studies involving simple coronary lesions indicate that a
sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary …

[HTML][HTML] Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents

…, SD Wiviott, DJ Cohen, DR Holmes Jr… - … England Journal of …, 2014 - Mass Medical Soc
Background Dual antiplatelet therapy is recommended after coronary stenting to prevent
thrombotic complications, yet the benefits and risks of treatment beyond 1 year are uncertain. …

Drugs for bad bugs: confronting the challenges of antibacterial discovery

DJ Payne, MN Gwynn, DJ Holmes… - Nature reviews Drug …, 2007 - nature.com
The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope
for antibacterial drug discoverers, who now had the tools to search entire genomes for new …

[HTML][HTML] Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease

…, AP Kappetein, A Colombo, DR Holmes… - New England journal …, 2009 - Mass Medical Soc
Background Percutaneous coronary intervention (PCI) involving drug-eluting stents is
increasingly used to treat complex coronary artery disease, although coronary-artery bypass …

2014 AHA/ACC guideline for the management of patients with non–ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American …

…, RG Brindis, DE Casey, TG Ganiats, DR Holmes… - Journal of the American …, 2014 - jacc.org
The recommendations listed in this CPG are, whenever possible, evidence based. An extensive
evidence review was conducted through October 2012, and other selected references …

A rapid boiling method for the preparation of bacterial plasmids

DS Holmes, M Quigley - Analytical biochemistry, 1981 - Elsevier
A simple and rapid method for preparing plasmids for restriction enzyme analysis has been
developed. Bacteria are boiled for 15–40 s and an insoluble clot of genomic DNA and debris …

Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction

…, ST Higano, RA Nishimura, DR Holmes Jr… - Circulation, 2000 - Am Heart Assoc
Background—Coronary endothelial dysfunction is characterized by vasoconstrictive response
to the endothelium-dependent vasodilator acetylcholine. Although endothelial dysfunction …

Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention

…, GW Barsness, V Mathew, KN Garratt, DR Holmes Jr - circulation, 2002 - Am Heart Assoc
Background— In patients undergoing percutaneous coronary intervention (PCI) in the modern
era, the incidence and prognostic implications of acute renal failure (ARF) are unknown. …

Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial

DR Holmes, VY Reddy, ZG Turi, SK Doshi, H Sievert… - The Lancet, 2009 - thelancet.com
Background In patients with non-valvular atrial fibrillation, embolic stroke is thought to be
associated with left atrial appendage (LAA) thrombi. We assessed the efficacy and safety of …

[BOOK][B] The Java programming language

K Arnold, J Gosling, D Holmes - 2005 - acs.ase.ro
… By Ken Arnold, James Gosling, David Holmes … Now, Ken Arnold, James Gosling, and
David Holmes have updated this classic to reflect the major enhancements in Java™ 2 …