Intensive care requirements for an ageing population–a microcosm of problems facing the NHS?

DJ Sparkes, GB Smith, D Prytherch - Clinical medicine, 2004 - ncbi.nlm.nih.gov
The changing patterns of admissions to an intensive care unit (ICU) were investigated in
relation to age. The local population and the patients admitted to ICU in each year from 1996 to …

Left medial temporal cytosolic choline in early onset depression

…, FP MacMaster, L Gates, SJ Sparkes… - The Canadian …, 2001 - journals.sagepub.com
… Ivan J Torres David J Bond … Michaelis T, Ohl F, Fuchs E, Frahm J. Brain metabolite
alterations after oral cortisol: A proton MRS study of tree shrews. Int Soc Magn Reson Med; …

Multiscale terrain and topographic modelling with the implicit TIN

DB Kidner, JM Ware, AJ Sparkes… - Transactions in …, 2000 - Wiley Online Library
The Multiscale Implicit Triangulated Irregular Network (TIN) provides a storage and access
scheme for generating triangulated terrain models that adapt their content and level of detail …

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

…, R Sparkes, E Spiegel, B Stevens, MR Stone, J Tagoe… - Nature …, 2017 - nature.com
Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their
characterization has largely been restricted to cytogenetic resolution. We explored the landscape …

An arsenical analogue of adenosine diphosphate

D Webster, MJ Sparkes, HBF Dixon - Biochemical Journal, 1978 - portlandpress.com
An analogue of ADP was made in which the terminal phosphono-oxy group, -O-PO(OH)2,
has been replaced by the arsonomethyl group, -CH2-AsO(OH)2. This compound cannot form …

9 New Multinationals for Old? The Political Economy of Japanese Internationalisation

H Mirza, PJ Bucldey, JR Sparkes - STUDIEs IN INTERNATIONAL BUSINESS - Springer
In the 1960s researchers suddenly discovered the multinational company (especially the
American variety, apparently in the process of engulfing Europe, if not the rest of the world) and …

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

…, O Parolini, RC Allen, I Klisak, RS Sparkes… - Cell, 1993 - cell.com
We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which
is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1, SH2…

An atlas of genetic influences on osteoporosis in humans and mice

…, NC Butterfield, KF Curry, VD Leitch, PC Sparkes… - Nature …, 2019 - nature.com
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

…, K Trajanoska, JG Logan, AS Pollard, PC Sparkes… - Nature …, 2017 - nature.com
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …

Schools, education and social exclusion

J Sparkes - LSE STICERD Research Paper No. CASE029, 1999 - papers.ssrn.com
A review of research evidence suggests that low levels of educational attainment are crucial
in generating and sustaining social exclusion. Test scores at school are the most effective …