Objective: To assess whether the association of serum homocysteine concentration with
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is causal …

OBJECTIVE: To quantify the incremental effect of combining blood pressure-lowering drugs
from any 2 classes of thiazides, beta-blockers, angiotensin-converting enzyme inhibitors, …

Background In acute ST-segment elevation myocardial infarction (STEMI), the use of
percutaneous coronary intervention (PCI) to treat the artery responsible for the infarct (infarct, or …

OBJECTIVE: Combination therapy, specifically with aspirin, cholesterol and blood pressure-lowering
drugs, substantially reduces the risk of coronary heart disease, but the full …

Background Child–parent screening for familial hypercholesterolemia has been proposed
to identify persons at high risk for inherited premature cardiovascular disease. We assessed …

Increasing intake of folic acid would be a relatively cheap and simple way of reducing heart
disease, if it works. Can we draw a definitive conclusion from the current evidence?

Background Lowering ser um homocysteine levels with folic acid is expected to reduce
mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic …

Importance Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated
genetic disorder that leads to premature morbidity and mortality due to atherosclerotic …

Objective To develop a population screening strategy for familial hypercholesterolaemia.
Design Meta-analysis of published data on total and low density lipoprotein (LDL) cholesterol …

Background A Polypill is proposed for the primary prevention of cardiovascular disease in
people judged to be at risk on account of their age alone. Its efficacy in reducing cholesterol …