The origin, termination, and length of axonal growth after focal central nervous system injury
was examined in adult rats by means of a new experimental model. When peripheral nerve …

Macrophages from the peripheral circulation and those derived from resident microglia are
among the main effector cells of the inflammatory response that follows spinal cord trauma. …

We present an extensive assessment of mutation burden through sequencing analysis of >81,000
tumors from pediatric and adult patients, including tumors with hypermutation caused …

The binding of [3H]serotonin to mouse brain crude membrane and synaptosomal membrane
preparations was investigated as a function of membrane fluidity changes by lipids. The …

Macrophages and microglia can be polarized along a continuum toward a detrimental (M1)
or a beneficial (M2) state in the injured CNS. Although phagocytosis of myelin in vitro …

Background Medulloblastoma is associated with rare hereditary cancer predisposition
syndromes; however, consensus medulloblastoma predisposition genes have not been defined …

Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We
have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin …

Adhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte
trafficking into the central nervous system. Using a lipid raft-based proteomic approach, we …

Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric
form. A glycosylphosphatidylinositol (GPI)-anchored form of this enzyme is expressed by …

Tissue transplantation methods, previously used to study neural development, myelination
and inherited disorders of myelin can be applied also to the investigation of repair and …