Comparing HIV‐1 and HIV‐2 infection: Lessons for viral immunopathogenesis

…, KL Flanagan, DC Macallan - Reviews in medical …, 2013 - Wiley Online Library
HIV‐1 and HIV‐2 share many similarities including their basic gene arrangement, modes of
transmission, intracellular replication pathways and clinical consequences: both result in …

Malnutrition in tuberculosis

DC Macallan - Diagnostic microbiology and infectious disease, 1999 - Elsevier
The link between tuberculosis and malnutrition has been recognized for very many years.
The Greeks referred to tuberculosis as “phthisis,” meaning, literally, to waste away and in the …

The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery

…, LS Taams, DC Macallan - Nature Reviews …, 2007 - nature.com
Whereas memory T cells are required to maintain immunity, regulatory T cells have to keep
the immune system in check to prevent excessive inflammation and/or autoimmunity. Both …

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

…, RA Flavell, DW Gilroy, B Asquith, D Macallan… - Journal of Experimental …, 2017 - rupress.org
In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …

[HTML][HTML] Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

…, PCL Beverley, DC Macallan… - The Journal of …, 2006 - Am Soc Clin Investig
While memory T cells are maintained by continuous turnover, it is not clear how human
regulatory CD4 + CD45RO + CD25 hi Foxp3 + T lymphocyte populations persist throughout life. …

[HTML][HTML] Energy expenditure and wasting in human immunodeficiency virus infection

DC Macallan, C Noble, C Baldwin… - … England Journal of …, 1995 - Mass Medical Soc
Background Increased expenditure of energy at rest has been considered a contributing
factor to the negative energy balance and weight loss that occur in patients with human …

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

…, DF Tough, PCL Beverley, DC Macallan - …, 2007 - Wiley Online Library
Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis.
We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium‐…

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

…, C Niederalt, B Asquith, D Macallan - Blood, The Journal …, 2016 - ashpublications.org
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates
vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling …

[HTML][HTML] BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

…, DC Palmer, JH Pan, SJ Patel, DC Macallan… - Nature …, 2016 - nature.com
T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8 + T cells. We hypothesized that access of signal-dependent …

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

DC Macallan, D Wallace, Y Zhang, C De Lara… - The Journal of …, 2004 - rupress.org
Memory T cells can be divided into central–memory (T CM ) and effector–memory (T EM )
cells, which differ in their functional properties. Although both subpopulations can persist long …