Comparing HIV‐1 and HIV‐2 infection: Lessons for viral immunopathogenesis
…, KL Flanagan, DC Macallan - Reviews in medical …, 2013 - Wiley Online Library
HIV‐1 and HIV‐2 share many similarities including their basic gene arrangement, modes of
transmission, intracellular replication pathways and clinical consequences: both result in …
transmission, intracellular replication pathways and clinical consequences: both result in …
Malnutrition in tuberculosis
DC Macallan - Diagnostic microbiology and infectious disease, 1999 - Elsevier
The link between tuberculosis and malnutrition has been recognized for very many years.
The Greeks referred to tuberculosis as “phthisis,” meaning, literally, to waste away and in the …
The Greeks referred to tuberculosis as “phthisis,” meaning, literally, to waste away and in the …
The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
…, LS Taams, DC Macallan - Nature Reviews …, 2007 - nature.com
Whereas memory T cells are required to maintain immunity, regulatory T cells have to keep
the immune system in check to prevent excessive inflammation and/or autoimmunity. Both …
the immune system in check to prevent excessive inflammation and/or autoimmunity. Both …
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
In humans, the monocyte pool comprises three subsets (classical, intermediate, and
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …
nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, …
[HTML][HTML] Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo
…, PCL Beverley, DC Macallan… - The Journal of …, 2006 - Am Soc Clin Investig
While memory T cells are maintained by continuous turnover, it is not clear how human
regulatory CD4 + CD45RO + CD25 hi Foxp3 + T lymphocyte populations persist throughout life. …
regulatory CD4 + CD45RO + CD25 hi Foxp3 + T lymphocyte populations persist throughout life. …
[HTML][HTML] Energy expenditure and wasting in human immunodeficiency virus infection
DC Macallan, C Noble, C Baldwin… - … England Journal of …, 1995 - Mass Medical Soc
Background Increased expenditure of energy at rest has been considered a contributing
factor to the negative energy balance and weight loss that occur in patients with human …
factor to the negative energy balance and weight loss that occur in patients with human …
In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection
…, DF Tough, PCL Beverley, DC Macallan - …, 2007 - Wiley Online Library
Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis.
We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium‐…
We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium‐…
Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives
…, C Niederalt, B Asquith, D Macallan - Blood, The Journal …, 2016 - ashpublications.org
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates
vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling …
vary from 4 to 18 hours. This dogma was recently challenged by stable isotope labeling …
[HTML][HTML] BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers
…, DC Palmer, JH Pan, SJ Patel, DC Macallan… - Nature …, 2016 - nature.com
T cell antigen receptor (TCR) signaling drives distinct responses depending on the
differentiation state and context of CD8 + T cells. We hypothesized that access of signal-dependent …
differentiation state and context of CD8 + T cells. We hypothesized that access of signal-dependent …
Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans
DC Macallan, D Wallace, Y Zhang, C De Lara… - The Journal of …, 2004 - rupress.org
Memory T cells can be divided into central–memory (T CM ) and effector–memory (T EM )
cells, which differ in their functional properties. Although both subpopulations can persist long …
cells, which differ in their functional properties. Although both subpopulations can persist long …