Neurological injuries have poor prognoses with serious clinical sequelae. Stem cell
transplantation enhances neural repair but is hampered by low graft survival (<ca. 5%), …

Penetrating traumatic brain injury (pTBI) causes serious neurological deficits with no clinical
regenerative therapies currently available. Tissue engineering strategies using biomaterial-…

Traumatic brain injuries are serious clinical incidents associated with some of the poorest
outcomes in neurological practice. Coupled with the limited regenerative capacity of the brain, …

Nanoparticle platforms are being intensively investigated for neurological applications. Current
biological models used to identify clinically relevant materials have major limitations, eg …

Introduction: Traumatic brain injury (TBI) Traumatic Brain Injury (TBI) can cause significant
disability and is a leading cause of death amongst under 40s. There is a clinical need to …

Injuries to the brain and spinal cord have major clinical consequences with high costs for
healthcare systems. Neural cell transplantation therapies have significant translational …

Aims Transplantation of neural stem cells (NSCs) into sites of neurological injury is being
investigated in clinical trials around the world. These important self-renewing and multipotent …

Intracerebral microinjections of gamma amino butyric acid were Given bilaterally at the medial
preoptic area (mPOA) to determine the possible role of this neurotran mitter in the genesis …

The development of safe technologies to genetically modify neurons is of high interest in
regenerative neurology, for both translational and basic science applications. Such approaches …

Tissue culture-grade plastics, media, and media supplements were from Fisher Scientific (Loughborough,
UK) and Sigma-Aldrich (Poole, UK). Recombinant human platelet-derived …