Rationale: Current asthma guidelines recommend adjusting antiinflammatory treatment on
the basis of the results of lung function tests and symptom assessment, neither of which are …

Background There is debate about the mechanisms of persistent airflow limitation in patients
with asthma. Chronic inflammation is assumed to be important, although there is limited …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Background In clinical trials, the use of inhaled corticosteroids is associated with an increased
risk of pneumonia in people with COPD, but whether the same is true for people with …

Rationale: New approaches are needed to guide personalized treatment of asthma.
Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: …

Background The development of tumor necrosis factor α (TNF-α) antagonists has made it
feasible to investigate the role of this cytokine in refractory asthma. Methods We measured …

Background: Non-eosinophilic asthma is a potentially important clinicopathological phenotype
since there is evidence that it responds poorly to inhaled corticosteroid therapy. However, …

Background Electronic monitoring of inhaled asthma medications is one method to measure
medication adherence and patterns of use. Information on the performance of monitors in a …

Background The Single combination budesonide–formoterol inhaler Maintenance And
Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but …

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional
and innovative systems biology approaches. A total of 99 school-age children with severe …