Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human
central nervous system (CNS). In MS, CNS inflammation is associated with demyelination …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system.
Current treatments are very effective in reducing the neuroinflammatory attack, but fail to …

Neurodegeneration in multiple sclerosis (MS) is related to inflammation and demyelination.
In acute MS lesions and experimental autoimmune encephalomyelitis focal immune attacks …

Cerebrospinal fluid (CSF) from healthy individuals contains between 1,000 and 3,000
leukocytes per ml. Little is known about trafficking patterns of leukocytes between the systemic …

Multiple sclerosis is the most common cause of non-traumatic neurological impairment in
young adults. An energy deficient state has been implicated in the degeneration of axons, the …

Objective Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS).
Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, …

It is unclear how immune cells traffic between the lymphoid compartment and the central
nervous system (CNS), which lacks lymphatic vessels and is shielded by the blood–brain barrier…

Mitochondrial content within axons increases following demyelination in the central nervous
system, presumably as a response to the changes in energy needs of axons imposed by …

Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in
amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN…

Axonal degeneration is a primary cause of permanent neurological disability in individuals
with the CNS demyelinating disease multiple sclerosis. Dysfunction of axonal mitochondria …