Smoking is one of the major lifestyle factors influencing the health of human beings. Life-long
cigarette smokers have a higher prevalence of common diseases such as atherosclerosis …

… Spruit PhD a , Miriam TJ Groenen MSc a , Emiel FM Wouters PhD, MD a b , Daisy JA
Janssen PhD, MD a c … DJ Janssen, MA Spruit, JM Schols, EF Wouters …

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity,
mortality, and resource use worldwide. The goal of this Official American Thoracic Society (…

Background: Pulmonary rehabilitation is recognized as a core component of the management
of individuals with chronic respiratory disease. Since the 2006 American Thoracic Society (…

The objective of the study was to further unravel the prognostic significance of body weight
changes in patients with COPD. Two survival analyses were performed: (1) a retrospective …

Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …

Background Acute exacerbations form a major component of the socioeconomic burden of
COPD. As yet, little information is available about the long-term outcome of patients who have …

Rationale: Comorbidities contribute to disease severity and mortality in patients with chronic
obstructive pulmonary disease (COPD). Comorbidities have been studied individually and …

Background Treatment with inhaled glucocorticoids in combination with long-acting
bronchodilators is recommended in patients with frequent exacerbations of severe chronic …

Quadriceps strength relates to exercise capacity and prognosis in chronic obstructive
pulmonary disease (COPD). We wanted to quantify the prevalence of quadriceps weakness in …