Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

Background Osteoarthritis (OA) is a degenerative joint disease involving the cartilage and
many of its surrounding tissues. Disease progression is usually slow but can ultimately lead to …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Introduction Epidemiological studies have shown that weaker grip strength in later life is
associated with disability, morbidity, and mortality. Grip strength is a key component of the …

Osteoporosis constitutes a major public health problem through its association with age-related
fractures, most notably those of the proximal femur. Substantial geographic variation has …

Osteoporosis is a major health problem, especially in elderly populations, and is associated
with fragility fractures at the hip, spine, and wrist. Hip fracture contributes to both morbidity …

A population‐based British cohort study, including ∼6% of the population, was used to derive
age‐ and sex‐specific incidence rates of fractures during childhood. Fractures were more …

Background All proposed definitions of sarcopenia include the measurement of muscle
mass, but the techniques and threshold values used vary. Indeed, the literature does not …

Osteoporosis is a major public health problem through associated fragility fractures. The most
common sites of fracture are the hip, spine and wrist, and these have an enormous health …

Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …