The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

…, MS Wiesener, GW Chang, SC Clifford, EC Vaux… - Nature, 1999 - nature.com
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including
the regulation of genes involved in energy metabolism, angiogenesis and apoptosis 1 , 2 , 3 …

[HTML][HTML] Sustainability in quality improvement: redefining value

…, J Isherwood, A Wilkinson, E Vaux - Future healthcare …, 2018 - ncbi.nlm.nih.gov
Sustainability can be considered a domain of quality in healthcare, extending the
responsibility of health services to patients not just of today but of the future. The longer term …

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

EC Vaux, E Metzen, KM Yeates… - Blood, The Journal of …, 2001 - ashpublications.org
Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to
hypoxia and has an important role in processes that include angiogenesis and erythropoiesis. …

[HTML][HTML] How to get started in quality improvement

B Jones, E Vaux, A Olsson-Brown - Bmj, 2019 - bmj.com
Quality improvement (box 1) is a core component of many undergraduate and postgraduate
curriculums. 1 2 3 4 5 Numerous healthcare organisations, 6 professional regulators, 7 and …

Use of real-time ultrasound guidance for the placement of hemodialysis catheters: a systematic review and meta-analysis of randomized controlled trials

KS Rabindranath, E Kumar, R Shail, E Vaux - American journal of kidney …, 2011 - Elsevier
BACKGROUND: Insertion of percutaneous hemodialysis catheters is an invasive procedure
with a small but definite risk of morbidity and mortality. OBJECTIVES: Assessing potential …

Effect of buttonhole cannulation with a polycarbonate PEG on in-center hemodialysis fistula outcomes: a randomized controlled trial

E Vaux, J King, S Lloyd, J Moore, L Bailey… - American journal of …, 2013 - Elsevier
BACKGROUND: Quality improvement strategies to increase and maintain the numbers of
arteriovenous fistulas (AVFs) are a critical drive in enhancing the quality of care of patients …

Ultrasound use for the placement of haemodialysis catheters

…, E Kumar, R Shail, EC Vaux - Cochrane Database of …, 2011 - cochranelibrary.com
Background A significant proportion of patients starting dialysis do so with a temporary or
tunnelled haemodialysis catheter. Insertion of these catheters can be achieved either by using …

Understanding the impact of haemodialysis on UK National Health Service patients' well‐being: A qualitative investigation

…, K Harvey, JP Harris, LT Butler, EC Vaux - Journal of clinical …, 2018 - Wiley Online Library
Aims and objectives While haemodialysis is an effective treatment for end‐stage renal disease,
the requirements and restrictions it imposes on patients can be onerous. The aim of this …

Building the bridge to quality: an urgent call to integrate quality improvement and patient safety education with clinical care

…, F Moss, G Ogrinc, KG Shojania, E Vaux… - Academic …, 2020 - journals.lww.com
Current models of quality improvement and patient safety (QIPS) education are not fully
integrated with clinical care delivery, representing a major impediment toward achieving …

Choosing Wisely and the climate crisis: a role for clinicians

KB Born, W Levinson, E Vaux - BMJ Quality & Safety, 2024 - qualitysafety.bmj.com
There are growing calls for healthcare to confront it’s role in the climate crisis. Estimates suggest
that carbon emissions from healthcare constitute 5% of net global emissions. To put this …