Background Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s
disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is …

Objective: To explore clinical phenotype and characteristics of Parkinson disease (PD) at
different ages at onset in recently diagnosed patients with untreated PD. Methods: We have …

The type 2 ryanodine receptor (RyR2) is a Ca 2+ release channel on the endoplasmic
reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In …

Post-mortem and neuroimaging studies suggest that the serotonergic system, which
originates from the brainstem raphe nuclei, is disrupted in Parkinson’s disease. This could …

Objective To investigate whether diabetes mellitus is associated with Parkinson-like pathology
in people without Parkinson disease and to evaluate the effect of diabetes mellitus on …

The clinical presentation of Parkinson’s disease (PD) is heterogeneous and overlaps with
other conditions, including the parkinsonian variant of multiple system atrophy (MSA-P), …

Currently, no reliable predictors of cognitive impairment in Parkinson’s disease exist. We
hypothesized that microstructural changes at grey matter T 1 -weighted MRI and diffusion …

Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle
inotropic reserve related to increased vascular afterload, arterial-ventricular load …

Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of the …

Background: The association between subclinical hypothyroidism (sHT) and cognitive impairment
or risk of dementia is not well-defined, especially in the elderly, where the assessment …