Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer
G Cox, JL Jones, KJ O'Byrne - Clinical cancer research, 2000 - AACR
Matrix metalloproteinase (MMP)-9 is an endopeptidase that digests basement membrane type
IV collagen. Enhanced expression has been related to tumor progression both in vitro and …
IV collagen. Enhanced expression has been related to tumor progression both in vitro and …
Hypoxia‐inducible factor‐1α in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
DEB Swinson, JL Jones, G Cox… - … journal of cancer, 2004 - Wiley Online Library
Hypoxia‐inducible factor (HIF)‐1α is the regulatory subunit of HIF‐1 that is stabilized under
hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis …
hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis …
Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: correlation with biological variables
DEB Swinson, JL Jones, D Richardson, G Cox… - Lung cancer, 2002 - Elsevier
Background: Tumour necrosis (TN) is recognized to be a consequence of chronic cellular
hypoxia. TN and hypoxia correlate with poor prognosis in solid tumours. Methods: In a …
hypoxia. TN and hypoxia correlate with poor prognosis in solid tumours. Methods: In a …
Effect of thoracoscopic talc poudrage vs talc slurry via chest tube on pleurodesis failure rate among patients with malignant pleural effusions: a randomized clinical trial
Importance Malignant pleural effusion (MPE) is challenging to manage. Talc pleurodesis is
a common and effective treatment. There are no reliable data, however, regarding the …
a common and effective treatment. There are no reliable data, however, regarding the …
Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways
…, MI Koukourakis, E Sivridis, K O'Byrne, G Cox… - Clinical Cancer …, 2000 - AACR
We investigated the expression of MUC1 protein and its relationship to the microvessel
density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF…
density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF…
[HTML][HTML] The use and development of medical thoracoscopy in the United Kingdom over the past 5 years
NJ Burrows, NJ Ali, GM Cox - Respiratory medicine, 2006 - Elsevier
INTRODUCTION: Medical thoracoscopy is a safe, reliable and therapeutic procedure used
in the management of pleural disease. For reasons that are unclear it is under utilised in the …
in the management of pleural disease. For reasons that are unclear it is under utilised in the …
Investigating the solitary pulmonary nodule
W McNulty, G Cox, I Au-Yong - BMj, 2012 - bmj.com
The presence of a solitary pulmonary nodule raises the suspicion of cancer and requires
careful further investigation to determine whether it is malignant or benign
careful further investigation to determine whether it is malignant or benign
[HTML][HTML] Serum proteomics and plasma fibulin-3 in differentiation of mesothelioma from asbestos-exposed controls and patients with other pleural diseases
…, I Psallidas, D Mukherjee, M Chetty, G Cox… - Journal of Thoracic …, 2021 - Elsevier
Introduction Malignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate
blood biomarker could prompt specialist referral or be deployed in future screening. In earlier …
blood biomarker could prompt specialist referral or be deployed in future screening. In earlier …
Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer
Introduction: The underlying biology of a tumour may hold the key to predicting the outcome
for an individual patient as well as identifying potential therapeutic targets. Using epidermal …
for an individual patient as well as identifying potential therapeutic targets. Using epidermal …
Does immunointensity account for the differences in prognostic significance of Bcl-2 expression in non-small cell lung cancer?
G Cox, RA Walker, S Muller, KR Abrams… - Pathology & Oncology …, 2000 - Springer
Bcl-2 is an oncogenic protein that plays a central role in apoptosis. The association of Bcl-2
expression and prognosis in non-small cell lung cancer (NSCLC) is unclear, with some …
expression and prognosis in non-small cell lung cancer (NSCLC) is unclear, with some …