Background & Aims: Hypergastrinemia occurs frequently in association with acid suppression
and Helicobacter infection, but its role in the progression to gastric atrophy and gastric …

We have previously described the only reported case of human proprotein convertase 1 (PC1)
deficiency, in a female (Subject A) with obesity, hypogonadism, hypoadrenalism, and …

Background & Aims: Fatty acids induce cholecystokinin (CCK) secretion and modify gastric
motility, but the chain length requirements for these effects are not known. Nor is it clear …

Both inhibitory (satiety) and stimulatory (orexigenic) factors from the gastrointestinal tract
regulate food intake. In the case of the satiety hormone cholecystokinin (CCK), these effects are …

… Am J Physiol Regul Integr Comp Physiol 2010; 299:R1423–R1439. … Am J Physiol
Regul Integr Comp Physiol 2011; 301:R394–R401. … Am J Physiol Regul Integr Comp …

Incompletely processed gastrins have been postulated to play a role in growth of the
gastrointestinal tract, but few studies have examined the effects of progastrin on mucosal …

Neuropeptides terminating in ‐Arg‐Phe‐NH 2 (‐RFamide) were first discovered in molluscan
nervous systems, but were soon recognized to occur widely throughout the invertebrates. …

Enteroendocrine cells of the gastrointestinal tract act as a luminal surveillance system responding
to either the presence or absence of food in the gut lumen. Collectively, their secretory …

The landmark discovery by Bayliss and Starling in 1902 of the first hormone, secretin,
emerged from earlier observations that a response (pancreatic secretion) following a stimulus (…

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene occur in most
colorectal cancers and lead to activation of β-catenin. Whereas several downstream targets of β…