Rationale: Acute lung injury is a common complication after severe trauma, which predisposes
patients to multiple organ failure. This syndrome largely accounts for the late mortality that …

Background COVID-19 pandemic has developed rapidly and the ability to stratify the most
vulnerable patients is vital. However, routinely used severity scoring systems are often low on …

Objective: To investigate the impact of circulating histones on cardiac injury and dysfunction
in a murine model and patients with sepsis. Design: Prospective, observational clinical study …

S100P, an EF-hand calcium-binding protein, has been reported to be associated with the
progression of many types of cancers. Transfection of an expression vector for S100P into a …

C-reactive protein (CRP) is an acute-phase protein that plays an important defensive role in
innate immunity against bacterial infection, but it is also upregulated in many noninfectious …

Streptococcus pneumoniae accounts for more deaths worldwide than any other single
pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. …

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality rate is …

Non‐gene‐editing microbiome engineering (NgeME) is the rational design and control of
natural microbial consortia to perform desired functions. Traditional NgeME approaches use …

HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their
exact physiological function remains unknown. In a first attempt to elucidate the function of …

The COVID‐19 pandemic has been the most significant health crisis in recent global history.
Early studies from Wuhan highlighted COVID‐19‐associated coagulopathy and a …