Background Tuberculous meningitis kills or disables more than half of those affected with the
disease. Previous studies have been too small to determine whether adjunctive treatment …

Background The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity
and mortality worldwide. Due to its large public health and societal implications, multidrug-…

The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific resistance …

Tuberculous meningitis (TM) is difficult to diagnose and treat; clinical features are non-specific,
conventional bacteriology is widely regarded as insensitive, and assessment of newer …

Tuberculous meningitis is especially common in young children and people with untreated
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease can …

Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth
and nineteenth centuries and remains a cause of high mortality in developing countries. In …

Tuberculous meningitis causes substantial mortality and morbidity in children and adults.
More research is urgently needed to better understand the pathogenesis of disease and to …

The aim of these guidelines is to describe a practical but evidence-based approach to the
diagnosis and treatment of central nervous system tuberculosis in children and adults. We …

Background The management of complex orthopedic infections usually includes a prolonged
course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is …