User profiles for Hayley Evans
 | Hayley EvansUniversity of Oxford Verified email at imm.ox.ac.uk Cited by 3130 |
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
MM Tiemessen, AL Jagger, HG Evans… - Proceedings of the …, 2007 - National Acad Sciences
CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) are potent suppressors of the adaptive
immune system, but their effects on innate immune cells are less well known. Here we …
immune system, but their effects on innate immune cells are less well known. Here we …
Identification of early neurodegenerative pathways in progressive multiple sclerosis
Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration, which
causes cumulative disability and is refractory to current treatments. Drug development to …
causes cumulative disability and is refractory to current treatments. Drug development to …
[PDF][PDF] Interleukin‐17+ CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
…, M Rajasekhar, T Garrood, HG Evans… - Arthritis & …, 2014 - Wiley Online Library
Objective Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the
association with HLA class II in rheumatoid arthritis (RA). Since IL‐17+ cells are considered …
association with HLA class II in rheumatoid arthritis (RA). Since IL‐17+ cells are considered …
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
HG Evans, T Suddason, I Jackson… - Proceedings of the …, 2007 - National Acad Sciences
Recently, a new lineage of CD4 + T cells has been described in the mouse that specifically
secretes IL-17 [T helper (Th) 17]. This discovery has led to a revision of the hypothesis that …
secretes IL-17 [T helper (Th) 17]. This discovery has led to a revision of the hypothesis that …
In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses
HG Evans, NJ Gullick, S Kelly… - Proceedings of the …, 2009 - National Acad Sciences
Th17 cells are a recently defined subset of proinflammatory T cells that contribute to pathogen
clearance and tissue inflammation by means of the production of their signature cytokine IL…
clearance and tissue inflammation by means of the production of their signature cytokine IL…
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Thousands of genetic variants have been identified, which contribute to the development of
complex diseases, but determining how to elucidate their biological consequences for …
complex diseases, but determining how to elucidate their biological consequences for …
[HTML][HTML] TNF-α blockade induces IL-10 expression in human CD4+ T cells
HG Evans, U Roostalu, GJ Walter, NJ Gullick… - Nature …, 2014 - nature.com
IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory
diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory …
diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce the anti-inflammatory …
Periodontitis‐associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14+ monocytes leading to enhanced Th17/IL‐17 responses
…, SD van Asten, LA Burns, HG Evans… - European journal of …, 2016 - Wiley Online Library
The Th17/IL‐17 pathway is implicated in the pathogenesis of periodontitis (PD), however
the mechanisms are not fully understood. We investigated the mechanism by which the …
the mechanisms are not fully understood. We investigated the mechanism by which the …
Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127low regulatory T cells
GJ Walter, HG Evans, B Menon, NJ Gullick… - Arthritis & …, 2013 - Wiley Online Library
Objective Despite the high frequency of CD4+ T cells with a regulatory phenotype (CD25+CD127
low FoxP3+) in the joints of patients with rheumatoid arthritis (RA), inflammation …
low FoxP3+) in the joints of patients with rheumatoid arthritis (RA), inflammation …
[HTML][HTML] Linking power Doppler ultrasound to the presence of Th17 cells in the rheumatoid arthritis joint
Background Power Doppler ultrasound (PDUS) is increasingly used to assess synovitis in
Rheumatoid Arthritis (RA). Prior studies have shown correlations between PDUS scores and …
Rheumatoid Arthritis (RA). Prior studies have shown correlations between PDUS scores and …