[PDF][PDF] Regulators of adult neurogenesis in the healthy and diseased brain.

HE Grote, AJ Hannan - Clinical & Experimental Pharmacology & …, 2007 - dept.wofford.edu
In recent decades evidence has accumulated demonstrating the birth and functional integration
of new neurons in specific regions of the adult mammalian brain, including the dentate …

Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism

TL Spires, HE Grote, NK Varshney… - Journal of …, 2004 - Soc Neuroscience
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by a CAG
repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. …

Gene–environment interactions, neuronal dysfunction and pathological plasticity in Huntington's disease

A Van Dellen, HE Grote… - Clinical and Experimental …, 2005 - Wiley Online Library
Huntington's disease (HD) is a fatal autosomal dominant disorder in which there is progressive
neurodegeneration producing motor, cognitive and psychiatric symptoms. The dynamic …

Dendritic spine pathology and deficits in experience‐dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

TL Spires, HE Grote, S Garry… - European Journal of …, 2004 - Wiley Online Library
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a CAG repeat
expansion coding for an expanded polyglutamine tract in the huntingtin protein. Dendritic …

Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

SE Lazic, HE Grote, C Blakemore… - European Journal of …, 2006 - Wiley Online Library
Previous work has demonstrated that the transgenic R6/1 mouse model of Huntington's
disease has decreased proliferation of neural precursor cells (NPCs) in the dentate gyrus of the …

Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine

HE Grote, ND Bull, ML Howard… - European Journal of …, 2005 - Wiley Online Library
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
trinucleotide repeat encoding an extended polyglutamine tract in the huntingtin protein. …

Decreased hippocampal cell proliferation in R6/1 Huntington's mice

SE Lazic, H Grote, RJE Armstrong, C Blakemore… - …, 2004 - journals.lww.com
In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative
disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse …

Deficits in experience-dependent cortical plasticity and sensory-discrimination learning in presymptomatic Huntington's disease mice

…, A Cybulska-Klosowicz, H Grote… - Journal of …, 2005 - Soc Neuroscience
Huntington's disease (HD) is one of a group of neurodegenerative diseases caused by an
expanded trinucleotide (CAG) repeat coding for an extended polyglutamine tract. The disease …

Covid-19: the communication needs of D/deaf healthcare workers and patients are being forgotten

H Grote, F Izagaren - bmj, 2020 - bmj.com
Helen Grote, neurology registrar1, … We need to ensure that in our response to covid-19,
the rights of those with hearing loss are not forgotten, say Helen Grote and Fizz Izagaren …

Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in …

SE Lazic, AOG Goodman, HE Grote, C Blakemore… - Brain research, 2007 - Elsevier
Reduced neuronal plasticity in the striatum, hippocampus, and neocortex is a common
feature of transgenic mouse models of Huntington’s disease (HD). Doublecortin (DCX) and …