Worldwide economic constraints on health care systems have highlighted the importance of
evidence-based medicine and evidence-based health policy. The resulting clinical trials and …

Objectives: Protests, riots and revolutions have long been a part of human history and are
increasing globally, yet their impact on mental health remains largely unknown. We therefore …

The glucocorticoid receptor (GR) is a hormone-inducible transcription factor involved in
metabolic and anti-inflammatory gene expression responses. To investigate what controls …

Background: There is no single generally accepted clinical definition of frailty. Previously
developed tools to assess frailty that have been shown to be predictive of death or need for …

A prospective analysis of risk factors for Alzheimer’s disease was a major objective of the
Canadian Study of Health and Aging, a nationwide, population-based study. Of 6,434 eligible …

Background Not all cognitively impaired people have dementia, but those who do not meet
current criteria for dementia have received little study. We report a comprehensive estimate of …

Between 1977 and 1984, 48 girls but only 26 boys were born to parents exposed to 2, 3, 7,
8 tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) in Seveso, Italy. 1 The 1976 industrial …

Objective. —To validate and refine previously derived clinical decision rules that aid the efficient
use of radiography in acute ankle injuries. Design. —Survey prospectively administered …

… the Departments of Epidemiology and Community Medicine (Drs Nair and McDowell) and
Medicine (Dr Wells), University of Ottawa (Ontario) Faculty of Medicine. Dr Stiell is a Career …

Background. Frailty and fitness are important attributes of older persons, but population
samples of their prevalence, attributes, and outcomes are limited. Methods. The authors report …