[HTML][HTML] Single-cell multi-omics analysis of the immune response in COVID-19
…, KF Baker, AT Hanrath, ICD Schim van der Loeff… - Nature medicine, 2021 - nature.com
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
First experience of COVID-19 screening of health-care workers in England
E Hunter, DA Price, E Murphy, IS van der Loeff… - The Lancet, 2020 - thelancet.com
Since March 10, 2020, the Newcastle upon Tyne Hospitals National Health Service (NHS)
Foundation Trust has been screening symptomatic health-care workers for severe acute …
Foundation Trust has been screening symptomatic health-care workers for severe acute …
[HTML][HTML] COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study
…, A Snell, C Adeney, IS van der Loeff… - The Lancet …, 2020 - thelancet.com
Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …
syndrome, which might contribute to morbidity and mortality. This study explores a specific …
[HTML][HTML] National Early Warning Score 2 (NEWS2) to identify inpatient COVID-19 deterioration: a retrospective analysis
KF Baker, AT Hanrath, IS van der Loeff, LJ Kay… - Clinical …, 2021 - ncbi.nlm.nih.gov
Methods Consecutive adult admissions with PCR-confirmed COVID-19 were included in
this single-centre retrospective UK cohort study. We analysed all electronic clinical …
this single-centre retrospective UK cohort study. We analysed all electronic clinical …
[HTML][HTML] COVID-19 management in a UK NHS foundation trust with a high consequence infectious diseases centre: A retrospective analysis
KF Baker, AT Hanrath, I Schim van der Loeff, SA Tee… - Medical …, 2021 - mdpi.com
Recent large national and international cohorts describe the baseline characteristics and
outcome of hospitalised patients with COVID-19, however there is limited granularity to these …
outcome of hospitalised patients with COVID-19, however there is limited granularity to these …
Clinical frailty, and not features of acute infection, is associated with late mortality in COVID‐19: a retrospective cohort study
…, C Lazaridis, IS van der Loeff… - Journal of cachexia …, 2022 - Wiley Online Library
Background Coronavirus disease 2019 (COVID‐19) is associated with excess mortality after
hospital discharge. Identification of patients at increased risk of death following hospital …
hospital discharge. Identification of patients at increased risk of death following hospital …
Evaluation of procalcitonin-guided antimicrobial stewardship in patients admitted to hospital with COVID-19 pneumonia
…, KF Baker, I Schim van der Loeff… - JAC-Antimicrobial …, 2021 - academic.oup.com
Background Procalcitonin is a biomarker that may be able to identify patients with COVID-19
pneumonia who do not require antimicrobials for bacterial respiratory tract co-infections. …
pneumonia who do not require antimicrobials for bacterial respiratory tract co-infections. …
[HTML][HTML] Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19
Accurate risk stratification in COVID-19 patients consists a major clinical need to guide
therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity …
therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity …
The long-term survival potential of mature T lymphocytes is programmed during development in the thymus
C Sinclair, M Saini, I Schim van der Loeff… - Science …, 2011 - science.org
The homeostatic maintenance of normal numbers of mature T lymphocytes in the immune
system depends on signaling from the T cell antigen receptor (TCR) and the interleukin-7 …
system depends on signaling from the T cell antigen receptor (TCR) and the interleukin-7 …
[HTML][HTML] Sars-cov-2 testing of 11,884 healthcare workers at an acute nhs hospital trust in england: a retrospective analysis
AT Hanrath, I Schim van der Loeff, DW Lendrem… - Frontiers in …, 2021 - frontiersin.org
Healthcare workers (HCWs) are known to be at increased risk of infection with SARS-CoV-2,
although whether these risks are equal across all roles is uncertain. Here we report a …
although whether these risks are equal across all roles is uncertain. Here we report a …