Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention
JP Leach, R Mohanraj, W Borland - Epilepsia, 2012 - Wiley Online Library
The potentially serious outcomes from ingestion of and dependence on toxins make this an
important topic for epileptologists. We must be aware of the potential for harm from …
important topic for epileptologists. We must be aware of the potential for harm from …
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
Background Valproate is widely accepted as a drug of first choice for patients with generalised
onset seizures, and its broad spectrum of efficacy means it is recommended for patients …
onset seizures, and its broad spectrum of efficacy means it is recommended for patients …
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded …
Background Carbamazepine is widely accepted as a drug of first choice for patients with
partial onset seizures. Several newer drugs possess efficacy against these seizure types but …
partial onset seizures. Several newer drugs possess efficacy against these seizure types but …
[HTML][HTML] The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy …
Background Valproate is a first-line treatment for patients with newly diagnosed idiopathic
generalised or difficult to classify epilepsy, but not for women of child-bearing potential …
generalised or difficult to classify epilepsy, but not for women of child-bearing potential …
[HTML][HTML] The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label …
Background Levetiracetam and zonisamide are licensed as monotherapy for patients with
focal epilepsy, but there is uncertainty as to whether they should be recommended as first-line …
focal epilepsy, but there is uncertainty as to whether they should be recommended as first-line …
Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy.
JP Leach, J Girvan, A Paul, MJ Brodie - Journal of Neurology …, 1997 - jnnp.bmj.com
OBJECTIVE: To assess the effect of different doses of gabapentin (GBP) on cognitive
function in treated epileptic patients. METHODS: Twenty seven patients with refractory partial …
function in treated epileptic patients. METHODS: Twenty seven patients with refractory partial …
Which electroencephalography (EEG) for epilepsy? The relative usefulness of different EEG protocols in patients with possible epilepsy
JP Leach, LJ Stephen, C Salveta… - Journal of Neurology …, 2006 - jnnp.bmj.com
Background and aim: Electroencephalography (EEG) is an essential investigative tool for
use in young people with epilepsy. This study assesses the effects of different EEG protocols …
use in young people with epilepsy. This study assesses the effects of different EEG protocols …
“No longer Gage”: an iron bar through the head: Early observations of personality change after injury to the prefrontal cortex
K O'Driscoll, JP Leach - BMJ, 1998 - bmj.com
In September 1848, in Cavendish, Vermont, an incident occurred which was to change our
understanding of the relation between mind and brain. Phineas P Gage, a 25 year old …
understanding of the relation between mind and brain. Phineas P Gage, a 25 year old …
Hippo pathway deficiency reverses systolic heart failure after infarction
JP Leach, T Heallen, M Zhang, M Rahmani… - Nature, 2017 - nature.com
Mammalian organs vary widely in regenerative capacity. Poorly regenerative organs, such
as the heart are particularly vulnerable to organ failure. Once established, heart failure …
as the heart are particularly vulnerable to organ failure. Once established, heart failure …