Myeloid derived suppressor cells (MDSC) were first described nearly two decades ago.
Until recently, however, descriptions of MDSC populations were found almost exclusively in …

Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent
signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 …

Immune‐mediated liver injury in hepatitis is due to activated T cells producing interferon‐γ (IFN‐γ).
It is important to identify negative feedback immune mechanisms that can regulate T …

Gangliosides, sialic acid-containing glycosphingolipids present in most cell membranes,
are thought to participate in the maintenance of immune privilege and tumor-induced …

Fulminant inflammation in the liver is often accompanied by the accumulation of IFN-γ-producing
T cells. The BALB/c-Tgfb1−/− mouse exhibits extensive, spontaneously developing …

Glycosaminoglycans (GAGs) located on cellular membranes and the extracellular matrix (ECM)
are able to interact with chemokines and pro-inflammatory cytokines, leading to local …

… James M. Cripps was, at the time this paper was prepared, Staff Laboratory Technician,
Sani tary Engineering Research Laboratory, Univer sity of California, Berkeley. He is presently …

The specific mechanisms that mediate CD4+ T-cell-mediated liver injury have not been fully
elucidated. CD4+ invariant natural killer T (iNKT) cells are required for liver damage in some …

Background/Aims: BALB/c mice with a homozygous deficiency in the Tgfb1 gene are a
model of fulminant autoimmune hepatitis (AIH), spontaneously and rapidly developing Th1‐…

A problem was identified where patient care was affected because of delays in receiving
specialist cardiology input. This report describes the experience of developing a specialist …