Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory chain…

Lipid metabolism in CNS is of particular interest because of the high concentration of lipids.
The importance of lipids in cell signaling and tissue physiology is demonstrated by many …

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …

Today there exists only one FDA-approved treatment for ischemic stroke; ie, the serine protease
tissue-type plasminogen activator (tPA). In the aftermath of the failed stroke clinical trials …

Albino noninbred weanling male and female rats were fed a basic grain diet (Group 1) or a
basic diet supplemented with 33% bracken fern [BF (Group 2)] or 0.1% quercetin [purity, >99…

The low-molecular-weight imidazoquinolinamine derivative, 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
(imiquimod, previously described as R-837), induced α-interferon (…

Background Health-care workers constitute a high-risk population for acquisition of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Capacity for acute …

Phospholipid degradation is an important promoter of neuronal death after transient cerebral
ischemia. Phospholipid hydrolysis by phospholipase A 2 (PLA 2 ) after transient cerebral …

Neuroprotection by citicoline (CDP‐choline) in transient cerebral ischemia has been
demonstrated previously. Citicoline has undergone several Phase III clinical trials for stroke, and is …

Phosphatidylcholine (PtdCho) is a major membrane phospholipid, and its loss is sufficient
in itself to induce cell death. PtdCho homeostasis is regulated by the balance between …