User profiles for Jan Münch

Jan Münch

Ulm University
Verified email at uni-ulm.de
Cited by 15493

[PDF][PDF] SARS-CoV-2 variants B. 1.351 and P. 1 escape from neutralizing antibodies

…, H Schrezenmeier, M Müller, A Kleger, J Münch… - Cell, 2021 - cell.com
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies
worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the …

[HTML][HTML] SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

…, H Lickert, TFE Barth, M Wagner, J Münch… - Nature …, 2021 - nature.com
Infection-related diabetes can arise as a result of virus-associated β-cell destruction.
Clinical data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …

[HTML][HTML] Semen-derived amyloid fibrils drastically enhance HIV infection

J Münch, E Rücker, L Ständker, K Adermann… - Cell, 2007 - cell.com
Sexual intercourse is the major route of HIV transmission. To identify endogenous factors
that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein …

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

…, A Zhao, L Jiang, O Zirafi, JT Stevens, J Münch… - Nature, 2011 - nature.com
Many globular and natively disordered proteins can convert into amyloid fibrils. These fibrils
are associated with numerous pathologies 1 as well as with normal cellular functions 2 , 3 , …

[HTML][HTML] Detection of SARS-CoV-2 in human breastmilk

…, JA Müller, S Stenger, K Steinhart, F Kirchhoff, J Münch - The Lancet, 2020 - thelancet.com
It remains unclear whether severe acute respiratory syndrome corona virus 2 (SARSCoV2)
can be shed into breastmilk and transmitted to a child through breastfeeding. Recent …

Virucidal efficacy of different oral rinses against severe acute respiratory syndrome coronavirus 2

…, JA Müller, R Groß, J Münch… - The Journal of …, 2020 - academic.oup.com
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
creates a significant threat to global health. Recent studies suggested the significance of throat …

[HTML][HTML] Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1

M Schindler, J Münch, O Kutsch, H Li, ML Santiago… - Cell, 2006 - cell.com
High-level immune activation and T cell apoptosis represent a hallmark of HIV-1 infection
that is absent from nonpathogenic SIV infections in natural primate hosts. The mechanisms …

[PDF][PDF] Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains

…, M Schindler, A Specht, WN Landford, J Münch… - Cell host & …, 2009 - cell.com
Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn, …

[HTML][HTML] Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

…, A Janssen, G Ssebyatika, G Bernhardt, J Münch… - Nature medicine, 2021 - nature.com
Currently approved viral vector-based and mRNA-based vaccine approaches against
coronavirus disease 2019 (COVID-19) consider only homologous prime-boost vaccination. After …

[HTML][HTML] TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

…, T Kimura, C Dinkins, G Silvestri, J Münch… - Developmental cell, 2014 - cell.com
Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for
degradation, plays a broad role in health and disease states. Here we screened the TRIM family …