Lipids have been used extensively for drug delivery in various forms such as liposomes,
and solid-matrices. The focus of this review is evaluation of liquid crystalline cubic phases, …

Aims Left-ventricular non-compaction (LVNC) is characterized by excessive and prominent
left-ventricular (LV) trabeculations and may be associated with systolic dysfunction in …

Tenofovir disoproxil fumarate (tenofovir DF) is an oral prodrug of tenofovir, a nucleotide (nucleoside
monophosphate) analogue with activity against retroviruses, including HIV-1, HIV-2 …

Aims Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in
patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from …

Background: Anderson–Fabry disease is an X-linked glycosphingolipid storage disorder
caused by deficient activity of the lysosomal enzyme α-galactosidase A. This leads to a …

Objective: To determine the range of survival rates of patients with hypertrophic cardiomyopathy
(HCM) by comparing and contrasting the natural history of a cohort of patients seen …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that
simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination and …

Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by a
deficiency in the enzyme α-galactosidase A. More than 60% of patients with AFD have evidence …

Background: Resting left ventricular outflow tract obstruction (LVOTO) occurs in 25% of
patients with hypertrophic cardiomyopathy (HCM) and is an important cause of symptoms and …

Objective: To measure coronary flow reserve (CFR), an index of microvascular function, in
Anderson-Fabry disease (AFD) at baseline and after enzyme replacement therapy (ERT). …