Purpose Physicians sometimes selectively convey prognostic information to support
patients' hopes. However, the relationship between prognostic disclosure and hope is not …

Purpose Physicians have an ethical obligation to honor patients' values for care, including
at the end of life (EOL). We sought to evaluate factors that help patients to receive care …

Purpose Concerns about the harms of prognostic information, including distress and loss of
hope, cause some physicians to avoid frank disclosure. We aimed to determine parent …

Context Talking about death can be difficult. Without evidence that end-of-life discussions
improve patient outcomes, physicians must balance their desire to honor patient autonomy …

Background: National guidelines recommend that physicians discuss end-of-life (EOL) care
planning with patients with cancer whose life expectancy is less than 1 year. Objective: To …

Background Chemotherapy for metastatic lung or colorectal cancer can prolong life by
weeks or months and may provide palliation, but it is not curative. Methods We studied 1193 …

Purpose National guidelines recommend that discussions about end-of-life (EOL) care
planning happen early for patients with incurable cancer. We do not know whether earlier EOL …

We assembled genome-wide data from 271 ancient Iberians, of whom 176 are from the
largely unsampled period after 2000 BCE, thereby providing a high-resolution time transect of …

Purpose To ascertain parents' and physicians' assessments of quality of end-of-life care for
children with cancer and to determine factors associated with high-quality care as perceived …

Purpose: To deepen our understanding of mutant ROS1 expression, localization, and
frequency in non–small cell lung cancer (NSCLC), we developed a highly specific and sensitive …