Background Blood transcriptional signatures are candidates for non-sputum triage or
confirmatory tests of tuberculosis. Prospective head-to-head comparisons of their diagnostic …

Background We describe drug-induced liver injury (DILI) secondary to antituberculous treatment
(ATT) in a large tuberculosis (TB) centre in London; we identify the proportion who had …

BACKGROUND. Novel rapid diagnostics for active tuberculosis (TB) are required to overcome
the time delays and inadequate sensitivity of current microbiological tests that are critically …

Background. The clinical epidemiology of acute renal failure (ARF) in human immunodeficiency
virus (HIV)-infected patients remains poorly defined. Methods. We conducted a …

The decision to treat active tuberculosis (TB) is dependent on microbiological tests for the
organism or evidence of disease compatible with TB in people with a high demographic risk of …

HIV infection profoundly affects many parameters of the immune system and ultimately leads
to AIDS, yet which factors are most important for determining resistance, pathology, and …

Background The highest risk of tuberculosis arises in the first few months after exposure.
We reasoned that this risk reflects incipient disease among tuberculosis contacts. Blood …

Successful treatment of HIV-associated multicentric Castleman disease (HIV+MCD) with
rituximab-based approaches has dramatically improved survival and reduced the risk of human …

Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to
deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 …

Objective: To identify risk factors for acute renal failure (ARF) in HIV-infected patients. Design:
Observational cohort study of HIV-infected patients attending a South London HIV centre …