Background The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding
domain, which is the target of enzalutamide and abiraterone, but remains constitutively …

Metastatic cancers adopt certain properties of normal cells in developing or regenerating
organs, such as the ability to proliferate and alter tissue organization. We find here that activity …

A gene from human chromosome 11p11.2 was isolated and was shown to suppress
metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, …

Objective The ability to make an early, accurate diagnosis of rheumatoid arthritis (RA) has
become increasingly important with the availability of new, expensive, and targeted therapies. …

The natural history of benign prostatic hyperplasia (BPH) involves two phases. The first, or
pathological phase of BPH, involves two stages, termed microscopic and macroscopic BPH, …

The rapid involution of the rat ventral prostate after castration is an active process initiated
by removal of the inhibitory effects of androgen on prostatic cell death. The present studies …

Despite thymic deletion of cells with specificity for self-antigens, autoreactive T cells are
readily detectable in the normal T-cell repertoire. In recent years, a population of CD4 + T cells …

The increased incidence of prostate cancer has led to remarkable changes in diagnosis
and treatment over the past century. What were the first ways in which prostate cancer was …

LITTLE is known about virus–host cell interactions that regulate the lytic potential of viruses
during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus …

Cells possess within their epigenetic repertoire the ability to undergo an active process of
cellular suicide termed programmed (or apoptotic) cell death. This programmed cell death …