… We thank the general practitioners at the St John’s Way Medical Centre, London N19, for …
for help with HbA1 assays, and Ms Harriet Yudkin for clencal help. We also thank Dr Peter …

C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of
interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown …

During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate
a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. To …

There is mounting evidence that inflammation plays a role in the development of coronary
heart disease (CHD). Observations have been made linking the presence of infections in the …

Objective: To determine the relation between systolic blood pressure over time and the risk
of macrovascular or microvascular complications in patients with type 2 diabetes. Design: …

Background To describe the frequency, in some European populations, of the World Health
Organisation (WHO) defined metabolic syndrome and to compare the frequency of this …

Adipose tissue expresses cytokines that inhibit insulin signalling pathways in liver and muscle.
Obesity also results in impairment of endothelium-dependent vasodilatation in response …

… We are grateful to Professor DJP Barker for help in seeking financial support for this project
and discussions about the design of the study, to Drs John and Simon Griffin for helping with …

Background: The higher risk of type 2 diabetes in persons with a high waist-to-hip ratio (WHR)
or waist-to-thigh ratio (WTR) has mostly been attributed to increased visceral fat …

Insulin resistance has been proposed as the metabolic basis of atherogenesis. This hypothesis
is based on the concept of the “insulin resistance syndrome,” according to which insulin …