White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes
form throughout life, with the most marked expansion of the lineage occurring during the …

TGFβ-related growth factors have been implicated in a variety of developmental and
physiological processes in organisms ranging from nematodes to mammals. TGFβ transduces its …

The Wnt signalling cascade is essential for the development of both invertebrates and
vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling …

Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms.
Once formed, the tissue is dynamic, responding to homeostatic and external cues and …

To gain insights into the genetic cascades that regulate fat biology, we evaluated C. elegans
as an appropriate model organism. We generated worms that lack two transcription factors, …

Background The expression of carcino-embryonic antigen by colorectal cancer is an example
of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-…

Xenopus cDNAs homologous to the Drosophila Mad gene and C. elegans CEM genes have
been cloned and functionally analyzed by microinjection into frog embryos. The results …

A 5-year retrospective study of 530 motor vehicle fatalities revealed 105 aortic injuries occurring
in 90 victims. These were reviewed to determine the injury patterns, circumstances, and …

We report the isolation of a Xenopus BMP receptor that is expressed maternally in the
appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and …

Hedgehog (Hh) signals regulate invertebrate and vertebrate development, yet the role of the
cascade in adipose development was undefined. To analyze a potential function, we turned …