Inflammatory bowel diseases are characterised by inflammation that compromises the
integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has …

Aliment Pharmacol Ther 2011; 34: 409–415 Summary Background Evidence is emerging
regarding the relationship between a dysbiosis of the human gut microbiota and a number of …

The intestinal immune system maintains a delicate balance between immunogenicity
against invading pathogens and tolerance of the commensal microbiota and food antigens. …

Scope The human/microbiota cross‐talk is partially mediated by bacteria‐derived peptides
like Serine‐Threonine peptide ( ST p), which is resistant to gut proteolysis, is found in the …

Objective Dendritic cells (DC) mediate intestinal immune tolerance. Despite striking
differences between the colon and the ileum both in function and bacterial load, few studies …

The pathogenesis of inflammatory bowel disease is incompletely understood but results
from a dysregulated intestinal immune response to the luminal microbiota. CD4 + T cells …

Background & Aims Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC)
relies on murine studies where CD103 + DC specialize in generating immune tolerance with …

Background: The medical management of refractory ulcerative colitis (UC) remains a significant
challenge. Two randomised controlled studies have demonstrated tacrolimus therapy is …

Clostridium difficile is a bacterial infection that colonises the gut in susceptible hosts. It is
associated with exposure to healthcare settings and antibiotic use. It could be assumed that …

Background. Dendritic cells regulate immune responses to microbial products and play a
key role in ulcerative colitis (UC) pathology. We determined the immunomodulatory effects of …