The inherited platelet disorders are an uncommon cause of symptomatic bleeding. They
may be difficult to diagnose (and are likely to be under‐diagnosed) and pose problems in …

We analyzed candidate platelet function disorder genes in 13 index cases with a history of
excessive bleeding in association with a significant reduction in dense granule secretion and …

Light transmission aggregometry (LTA) is used worldwide for the investigation of heritable
platelet function disorders (PFDs), but interpretation of results is complicated by the feedback …

We investigated whether defects in the P2Y 12 ADP receptor gene (P2RY12) contribute to
the bleeding tendency in 92 index cases enrolled in the European MCMDM-1VWD study. A …

Despite the development of highly effective treatment strategies for acute promyelocytic
leukaemia around 10% of patients die in the presentation period as a consequence of the …

Pseudo‐von Willebrand disease (p‐VWD) and type 2B von Willebrand disease (VWD) have
similar phenotypic parameters and clinical symptoms, but different aetiologies. Fourteen …

The impact of HIV on mortality rates in the complete UK haemophilia population. - Abstract -
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The lower temperatures utilized during profound hypothermic circulatory arrest (PHCA)
surgery may exacerbate the hypothermia associated platelet and clotting factor dysfunction …

We examined recombinant activated factor VII (rVIIa) administered by continuous infusion to
eight patients with inhibitors to factor VIII, undergoing elective surgery. rVIIa was infused at a …

The use of protease inhibitor (PI) drugs in treatment regimens for HIV‐infected patients with
hereditary bleeding disorders has been associated with an increased bleeding tendency. To …