CONTEXT: A literature review and environmental scan were conducted to develop a
framework for interventions that utilize linkages between clinical practices and community …

Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem
that is exacerbated when engineering large tissue constructs for clinical application. Here …

In animals, electron transfer from NADH to molecular oxygen proceeds via large respiratory
complexes in a linear respiratory chain. In contrast, most fungi utilise branched respiratory …

This paper reviews the current status of our understanding of azole antifungal resistance
mechanisms at the molecular level and explores their implications. Extensive biochemical …

Malaria caused by Plasmodium vivax is a major cause of global morbidity and, in rare cases,
mortality. Lactate dehydrogenase is an essential Plasmodium protein and, therefore, a …

BACKGROUND: Various studies have reported a prevalence of polycystic ovaries (PCO) of
∼20% in the `normal' population. Our aim was to investigate the frequency of ovulation and …

The storage tissues of many plants contain protease inhibitors that are believed to play an
important role in defending the plant from invasion by pests and pathogens. These …

Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen
Cryptococcus neoformans, and accumulation of a ketosteroid product was associated with …

Mitochondrial transfer of electrons from NAD(P)H or FADH 2 to the terminal electron acceptor,
oxygen, follows a highly complex scheme, involving numerous redox components. Whilst …

Azole antifungals inhibit CYP51A1‐mediated sterol 14α‐demethylation and the mechanism(s)
of resistance to such compounds in Ustilago maydis were examined. The inhibition of …